Orthobiologics or Surgery? When to Operate and When to Regenerate

with James Guthrie and Meg Brady

In this episode of The Nupsala Podcast, host Meg Brady, BSc (Hons), RVN, PGCert, is joined by Dr James Guthrie BVM&S MBA CertAVP(GSAS) PgCertVBM CCRT DipECVS DipACVSMR DipECVSMR MAcadMEd FRSB FRSA FRCVS, Senior Orthopaedic Surgeon at Fitzpatrick Referrals, for an in-depth discussion on treatment decision-making in canine joint disease.

Together, they explore one of the most common challenges facing veterinary professionals managing musculoskeletal conditions: when is surgery the most appropriate option, and where might orthobiologics fit within the treatment pathway? Drawing on his experience in orthopaedic surgery, sports medicine and rehabilitation, James shares practical insights into balancing risk, reward, disease stage, and patient-specific factors when developing treatment plans.

This episode covers:

  • How treatment goals and decision-making change throughout the progression of joint disease
  • When surgery may be indicated and when alternative approaches may be considered
  • The role of PRP, stem cells, and other intra-articular therapies in clinical practice
  • The importance of diagnosis, disease staging, and patient selection
  • Combining surgery, rehabilitation, medication, and orthobiologics within a multimodal treatment plan


Whether you’re working in general practice, referral practice, rehabilitation, or sports medicine, this episode offers practical insights into navigating an expanding range of treatment options for dogs with joint disease.

About the guest

James Guthrie

BVM&S MBA CertAVP(GSAS) PgCertVBM CCRT DipECVS DipACVSMR DipECVSMR MAcadMEd FRSB FRSA FRCVS

RCVS Recognised Specialist in Small Animal Surgery

Dr James Guthrie is one of Europe's most highly qualified veterinary specialists and the only veterinarian in the UK to hold diplomate status in both Small Animal Surgery and Canine Sports Medicine and Rehabilitation. His clinical focus is on maximising patient outcomes through minimally invasive surgery, regenerative medicine, and evidence-based rehabilitation. A graduate of the University of Edinburgh, James is an RCVS Specialist in Small Animal Surgery and a diplomate of both the European and American Colleges of Veterinary Sports Medicine and Rehabilitation. Alongside his clinical work, he is actively involved in teaching, mentoring specialist trainees, and supporting veterinary students. He has published widely in peer-reviewed journals, presented internationally, and is a Member of the Academy of Medical Educators.

Explore more

Breaking the Silence on Endometriosis: From Awareness to Action

The Nupsala Podcast Bite Sized: Polyacrylamide Hydrogels

The Nupsala Podcast Episode 4: The Current Landscape of Intra-Articular Therapy in Small Animals

The Nupsala Podcast | Episode 3 Canine Regenerative Medicine in Practice

Dog Sleep & Pain: The Overlooked Connection in Osteoarthritis Care

HorStem equine regenerative therapy with Almudena Pradera

Sleep and Osteoarthritis Webinar

The Science Behind HorStem: Why This Licensed Equine Stem Cell Therapy is Different

How to apply for a Special Import Certificate

Want to request content?

We’re always looking to grow Nupsala Learning with content that matters to you. If there’s a topic, treatment, or clinical area you’d like us to cover, let us know.

Our team of experts is ready to create the resources you need to stay informed and at the forefront of veterinary care.

Nupsala is the proud operator of Nupsala Learning, for all your wholesale needs please visit nupsala.com (UK) or nupsala-eu.com (EU)

Veterinary Professionals Only

Licensed veterinary professionals only.
Confirm below to continue.